CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway. Richardson CD, Kazane KR, Feng SJ, Zelin E, Bray NL, Schäfer AJ, Floor SN, Corn JE. Nat Genet. 2018 Aug;50(8):1132-1139.
Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes. Richardson CD, Ray GJ, Bray NL, Corn JE. Nat Commun. 2016 Aug 17;7:12463.
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA. Richardson CD, Ray GJ, DeWitt MA, Curie GL, Corn JE.Nat Biotechnol. 2016 Mar;34(3):339-44.
Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. Richardson CD, Li JJ. PLoS Genet. 2014 Jun 19;10(6):e1004358.
Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair. Beeke Wienert, Sharon J Feng, Melissa Locke, David N Nguyen, Stacia K Wyman, Katelynn R Kazane, Alex Marson, Chris D Richardson, Jacob E Corn.
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Beeke Wienert, Stacia K Wyman, Christopher D Richardson, Charles D Yeh, Pinar Akcakaya, Michelle J Porritt, Michaela Morlock, Jonathan T Vu, Katelynn R Kazane, Hannah L Watry, Luke M Judge, Bruce R Conklin, Marcello Maresca, Jacob E Corn.
Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes. CD Richardson, GJ Ray, JE Corn.
CRISPR-Cas9 Genome Editing In Human Cells Works Via The Fanconi Anemia Pathway. Chris D. Richardson, Katelynn R. Kazane, Sharon J. Feng, Nicholas L. Bray, Axel J. Schaefer, Stephen Floor, Jacob E Corn.