Selected Publications

A genome-wide screen links peroxisome regulation with Wnt signaling through RNF146 and TNKS/2. Vu JT, Tavasoli KU, Sheedy CJ, Chowdhury SP, Mandjikian L, Bacal J, Morrissey MA, Richardson CD*, Gardner BM*. J Cell Biol. 2024 Oct 7;223(10):e202312069.

Interstrand crosslinking of homologous repair template DNA enhances gene editing in human cells. Ghasemi HI, Bacal J, Yoon AC, Tavasoli KU, Cruz C, Vu JT, Gardner BM, Richardson CD. Nat Biotechnol. 2023 Oct;41(10):1398-1404. 

The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells. Wang AS, Chen LC, Wu RA, Hao Y, McSwiggen DT, Heckert AB, Richardson CD, Gowen BG, Kazane KR, Vu JT, Wyman SK, Shin JJ, Darzacq X, Walter JC, Corn JE. Mol Cell. 2020 Jun 23:S1097-2765(20)30399-3.

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs. Rose JC, Popp NA, Richardson CD, Stephany JJ, Mathieu J, Wei CT, Corn JE, Maly DJ, Fowler DM. Nat Commun. 2020 Jun 1;11(1):2697.

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair. Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE. Nat Commun. 2020 Apr 30;11(1):2109.

Advances in genome editing through control of DNA repair pathways. Yeh CD, Richardson CD, Corn JE. Nat Cell Biol. 2019 Dec;21(12):1468-1478.

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE. Science. 2019 Apr 19;364(6437):286-289.

CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway. Richardson CD, Kazane KR, Feng SJ, Zelin E, Bray NL, Schäfer AJ, Floor SN, Corn JE. Nat Genet. 2018 Aug;50(8):1132-1139.

Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes. Richardson CD, Ray GJ, Bray NL, Corn JE. Nat Commun. 2016 Aug 17;7:12463.

Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA. Richardson CD, Ray GJ, DeWitt MA, Curie GL, Corn JE.Nat Biotechnol. 2016 Mar;34(3):339-44.

Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. Richardson CD, Li JJ. PLoS Genet. 2014 Jun 19;10(6):e1004358.

Preprints

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair. Beeke Wienert, Sharon J Feng, Melissa Locke, David N Nguyen, Stacia K Wyman, Katelynn R Kazane, Alex Marson, Chris D Richardson, Jacob E Corn.

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Beeke Wienert, Stacia K Wyman, Christopher D Richardson, Charles D Yeh, Pinar Akcakaya, Michelle J Porritt, Michaela Morlock, Jonathan T Vu, Katelynn R Kazane, Hannah L Watry, Luke M Judge, Bruce R Conklin, Marcello Maresca, Jacob E Corn.

Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes. CD Richardson, GJ Ray, JE Corn.

CRISPR-Cas9 Genome Editing In Human Cells Works Via The Fanconi Anemia Pathway. Chris D. Richardson, Katelynn R. Kazane, Sharon J. Feng, Nicholas L. Bray, Axel J. Schaefer, Stephen Floor, Jacob E Corn.

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